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As referências que usamos

Publicado em 27/09/2026

As referências que usamos

Blog · Referências

As referências que usamos

Estas são as publicações que consultamos ao decidir a quantidade de cada constituinte das nossas fórmulas, organizadas por nutriente. Estudo não é promessa. A quantidade usada em pesquisa nem sempre é a de um suplemento, e nenhuma destas publicações foi feita com um produto nosso.

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Coenzima Q10 4Fosfatidilserina 5Magnésio 8Vitamina B6 2Vitamina C 2Vitamina D 8Vitamina K 1Zinco 6Triptofano 1Curcumina 3Folato (vitamina B9) 2Vitamina B12 1Selênio 1

Coenzima Q10

4 publicações−
  1. 1. Tsai I-C, Hsu C-W, Chang C-H, Tseng P-T, Chang K-V. Effectiveness of coenzyme Q10 supplementation for reducing fatigue: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. 2022;13:883251. doi:10.3389/fphar.2022.883251
  2. 2. Mehrabani S, Askari G, Miraghajani M, Tavakoly R, Arab A. Effect of coenzyme Q10 supplementation on fatigue: a systematic review of interventional studies. Complement Ther Med. 2019;43:181-7. doi:10.1016/j.ctim.2019.01.022
  3. 3. Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, Kuratsune H, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. BioFactors. 2016;42(4):431-40. doi:10.1002/biof.1293
  4. 4. Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008;24(4):293-9. doi:10.1016/j.nut.2007.12.007

Fosfatidilserina

5 publicações−
  1. 5. Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T, et al. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010;47(3):246-55. doi:10.3164/jcbn.10-62
  2. 6. Baumeister J, Barthel T, Geiss K-R, Weiss M. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neurosci. 2008;11(3):103-10. doi:10.1179/147683008X301478
  3. 7. Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, et al. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004;7(2):119-26. doi:10.1080/10253890410001728379
  4. 8. Monteleone P, Maj M, Beinat L, Natale M, Kemali D. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol. 1992;42(4):385-8. doi:10.1007/BF00280123
  5. 9. Duan H, Xu N, Yang T, Wang M, Zhang C, Zhao J, et al. Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: a randomized double-blind, placebo-controlled trial. J Affect Disord. 2025;369:35-42. doi:10.1016/j.jad.2024.09.131

Magnésio

8 publicações−
  1. 10. Noah L, Dye L, Bois De Fer B, Mazur A, Pickering G, Pouteau E. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: post-hoc analysis of a randomised controlled trial. Stress Health. 2021;37(5):1000-9. doi:10.1002/smi.3051
  2. 11. Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, Hellhammer J, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: a randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. doi:10.1371/journal.pone.0208454
  3. 12. Boyle NB, Lawton C, Dye L. The effects of magnesium supplementation on subjective anxiety and stress — a systematic review. Nutrients. 2017;9(5):429. doi:10.3390/nu9050429
  4. 13. Rukat M, Przyborowska K, Kwiecień J, Getka B, Wiejak K, Łata M, et al. The relationship between magnesium deficiency and anxiety, the therapeutic effects of magnesium supplementation — literature review. J Educ Health Sport. 2024;53:91-101. doi:10.12775/JEHS.2024.53.007
  5. 14. Severiano ACC, Figueiredo Júnior HS. Magnésio e depressão: uma revisão integrativa. Rev Ibero-Am Hum Ciênc Educ. 2024;10(1):1522-30. doi:10.51891/rease.v10i1.13068
  6. 15. Cheungpasitporn W, Thongprayoon C, Mao M, Srivali N, Ungprasert P, Varothai N, et al. Hypomagnesaemia linked to depression: a systematic review and meta-analysis. Intern Med J. 2015;45(4):436-40. doi:10.1111/imj.12682
  7. 16. Derom M-L, Sayón-Orea C, Martínez-Ortega JM, Martínez-González MA. Magnesium and depression: a systematic review. Nutr Neurosci. 2013;16(5):191-206. doi:10.1179/1476830512Y.0000000044
  8. 17. Chen F, Wang J, Cheng Y, Li R, Wang Y, Chen Y, et al. Magnesium and cognitive health in adults: a systematic review and meta-analysis. Adv Nutr. 2024;15(8):100272. doi:10.1016/j.advnut.2024.100272

Zinco

6 publicações−
  1. 31. Azargoonjahromi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024;82(5):612-21. doi:10.1093/nutrit/nuad076
  2. 32. de Vargas LS, Jantsch J, Fontoura JR, Dorneles GP, Peres A, Guedes RP. Effects of zinc supplementation on inflammatory and cognitive parameters in middle-aged women with overweight or obesity. Nutrients. 2023;15(20):4396. doi:10.3390/nu15204396
  3. 33. Russo AJ. Decreased zinc and increased copper in individuals with anxiety. Nutr Metab Insights. 2011;4:NMI.S6349. doi:10.4137/NMI.S6349
  4. 34. Tahmasebi K, Amani R, Nazari Z, Ahmadi K, Moazzen S, Mostafavi S-A. Association of mood disorders with serum zinc concentrations in adolescent female students. Biol Trace Elem Res. 2017;178(2):180-8. doi:10.1007/s12011-016-0917-7
  5. 35. Swardfager W, Herrmann N, Mazereeuw G, Goldberger K, Harimoto T, Lanctôt KL. Zinc in depression: a meta-analysis. Biol Psychiatry. 2013;74(12):872-8. doi:10.1016/j.biopsych.2013.05.008
  6. 36. Lai J, Moxey A, Nowak G, Vashum K, Bailey K, McEvoy M. The efficacy of zinc supplementation in depression: systematic review of randomised controlled trials. J Affect Disord. 2012;136(1-2):e31-9. doi:10.1016/j.jad.2011.06.022

Vitamina B12

1 publicação−
  1. 43. Markun S, Gravestock I, Jäger L, Rosemann T, Pichierri G, Burgstaller JM. Effects of vitamin B12 supplementation on cognitive function, depressive symptoms, and fatigue: a systematic review, meta-analysis, and meta-regression. Nutrients. 2021;13(3):923. doi:10.3390/nu13030923

Vitamina B6

2 publicações−
  1. 18. Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, Zheng Y, et al. High-dose vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37(6):e2852. doi:10.1002/hup.2852
  2. 19. Zhao L, Guan L, Sun J, Li X. Serum levels of folate, vitamin B6, and vitamin B12 are associated with cognitive impairments in depression patients. Acta Neuropsychiatr. 2024;36(1):44-50. doi:10.1017/neu.2023.41

Vitamina C

2 publicações−
  1. 20. De Oliveira IJL, de Souza VV, Motta V, Da-Silva SL. Effects of oral vitamin C supplementation on anxiety in students: a double-blind, randomized, placebo-controlled trial. Pak J Biol Sci. 2015;18(1):11-8. doi:10.3923/pjbs.2015.11.18
  2. 21. Moritz B, Schwarzbold M, Guarnieri R, Diaz A, Rodrigues AL. Effects of ascorbic acid on anxiety state and affect in a non-clinical sample. Acta Neurobiol Exp (Wars). 2017;77(4):362-72. doi:10.21307/ane-2017-068

Vitamina D

8 publicações−
  1. 22. Charoenporn V, Tungsukruthai P, Teacharushatakit P, Hanvivattanakul S, Sriyakul K, Sukprasert S, et al. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: a randomized controlled trial. Psychiatry Clin Neurosci. 2024;78(10):595-604. doi:10.1111/pcn.13716
  2. 23. Silva ABJ, Barros WMA, Silva ML, Silva JML, Souza APS, Silva KG, et al. Impact of vitamin D on cognitive functions in healthy individuals: a systematic review in randomized controlled clinical trials. Front Psychol. 2022;13:987203. doi:10.3389/fpsyg.2022.987203
  3. 24. Hansen AL, Ambroziak G, Thornton D, Mundt JC, Kahn RE, Dahl L, et al. Vitamin D supplementation during winter: effects on stress resilience in a randomized control trial. Nutrients. 2020;12(11):3258. doi:10.3390/nu12113258
  4. 25. Zhu C, Zhang Y, Wang T, Lin Y, Yu J, Xia Q, et al. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. Brain Behav. 2020;10(11):e01760. doi:10.1002/brb3.1760
  5. 26. Esnafoglu E, Ozturan DD. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents. Child Adolesc Ment Health. 2020;25(4):249-55. doi:10.1111/camh.12387
  6. 27. Srifuengfung M, Srifuengfung S, Pummangura C, Pattanaseri K, Oon-Arom A, Srisurapanont M. Efficacy and acceptability of vitamin D supplements for depressed patients: a systematic review and meta-analysis of randomized controlled trials. Nutrition. 2023;108:111968. doi:10.1016/j.nut.2022.111968
  7. 28. Jorde R, Sneve M, Figenschau Y, Svartberg J, Waterloo K. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. J Intern Med. 2008;264(6):599-609. doi:10.1111/j.1365-2796.2008.02008.x
  8. 29. Yang T, Wang H, Xiong Y, Chen C, Duan K, Jia J, et al. Vitamin D supplementation improves cognitive function through reducing oxidative stress regulated by telomere length in older adults with mild cognitive impairment: a 12-month randomized controlled trial. J Alzheimers Dis. 2020;78(4):1509-18. doi:10.3233/JAD-200926

Vitamina K

1 publicação−
  1. 30. Azuma K, Osuka Y, Kojima N, Sasai H, Kim H, Inoue S. Association of vitamin K insufficiency with cognitive dysfunction in community-dwelling older adults. Front Nutr. 2022;8:811831. doi:10.3389/fnut.2021.811831

Triptofano

1 publicação−
  1. 37. Kikuchi AM, Tanabe A, Iwahori Y. A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning. J Diet Suppl. 2021;18(3):316-33. doi:10.1080/19390211.2020.1746725

Curcumina

3 publicações−
  1. 38. Matias JN, Achete G, Campanari GSS, Guiguer EL, Araújo AC, Buglio DS, et al. A systematic review of the antidepressant effects of curcumin: beyond monoamines theory. Aust N Z J Psychiatry. 2021;55(5):451-62. doi:10.1177/0004867421998795
  2. 39. Zhang Y, Li L, Zhang J. Curcumin in antidepressant treatments: an overview of potential mechanisms, pre-clinical/clinical trials and ongoing challenges. Basic Clin Pharmacol Toxicol. 2020;127(4):243-53. doi:10.1111/bcpt.13455
  3. 40. Fusar-Poli L, Vozza L, Gabbiadini A, Vanella A, Concas I, Tinacci S, et al. Curcumin for depression: a meta-analysis. Crit Rev Food Sci Nutr. 2020;60(15):2643-53. doi:10.1080/10408398.2019.1653260

Folato (vitamina B9)

2 publicações−
  1. 41. Bender A, Hagan KE, Kingston N. The association of folate and depression: a meta-analysis. J Psychiatr Res. 2017;95:9-18. doi:10.1016/j.jpsychires.2017.07.019
  2. 42. Xu M, Zhu Y, Chen J, Li J, Qin J, Fan Y, et al. Effects of folic acid supplementation on cognitive impairment: a meta-analysis of randomized controlled trials. J Evid Based Med. 2024;17(1):134-44. doi:10.1111/jebm.12588

Selênio

1 publicação−
  1. 44. Pereira ME, Souza JV, Galiciolli MEA, Sare F, Vieira GS, Kruk IL, et al. Effects of selenium supplementation in patients with mild cognitive impairment or Alzheimer's disease: a systematic review and meta-analysis. Nutrients. 2022;14(15):3205. doi:10.3390/nu14153205

Cada referência traz o identificador DOI, que leva ao artigo original. Os títulos estão na língua em que foram publicados.